List of Compassionate Allowance Medical Conditions
(CAL Diseases, Disorders, and Impairments)
This list is current as of September 2, 2025. Please visit the SSA.gov website for updates.
- 1p36 Deletion Syndrome
- Acute Leukemia
- Adrenal Cancer - with distant metastases or inoperable, unresectable or recurrent
- Adult Heart Transplant Wait List – Status Levels 1-4 (New)
- Adult Non-Hodgkin Lymphoma
- Adult Onset Huntington Disease
- Aicardi-Goutieres Syndrome
- Alexander Disease (ALX) - Neonatal and Infantile
- Allan-Herndon-Dudley Syndrome
- Alobar Holoprosencephaly
- Alpers Disease
- Alpha Mannosidosis - Type II and III
- ALS/Parkinsonism Dementia Complex
- Alstrom Syndrome
- Alveolar Soft Part Sarcoma
- Amegakaryocytic Thrombocytopenia
- Amyotrophic Lateral Sclerosis (ALS)
- Anaplastic Adrenal Cancer - Adult with distant metastases or inoperable, unresectable or recurrent
- Anaplastic Ependymoma
- Angelman Syndrome
- Angioimmunoblastic T-Cell Lymphoma
- Angiosarcoma
- Aortic Atresia
- Aplastic Anemia
- Astrocytoma - Grade III and IV
- Ataxia Telangiectasia
- Atypical Teratoid/Rhabdoid Tumor
- Au-Kline Syndrome (New)
- Bainbridge-Ropers Syndrome (New)
- Batten Disease
- Beta Thalassemia Major
- Bilateral Anophthalmia (New)
- Bilateral Optic Atrophy- Infantile
- Bilateral Retinoblastoma
- Bladder Cancer - with distant metastases or inoperable or unresectable
- Blastic Plasmacytoid Dendritic Cell Neoplasm
- Breast Cancer - with distant metastases or inoperable or unresectable
- CACH—Vanishing White Matter Disease-Infantile and Childhood Onset Forms
- Calciphylaxis
- Canavan Disease (CD)
- Carcinoma of Unknown Primary Site
- Cardiac Amyloidosis- AL Type
- Caudal Regression Syndrome - Types III and IV
- Carey-Fineman-Ziter Syndrome (New)
- CDKL5 Deficiency Disorder
- Cerebro Oculo Facio Skeletal (COFS) Syndrome
- Cerebrotendinous Xanthomatosis
- Charlevoix-Saguenay Spastic Ataxia
- Child Heart Transplant Wait List – Status Levels 1A/1B
- Child Lymphoblastic Lymphoma
- Child Lymphoma
- Child Neuroblastoma - with distant metastases or recurrent
- Cholangiocarcinoma
- Chondrosarcoma - with multimodal therapy
- Choroid Plexus Carcinoma
- Chronic Idiopathic Intestinal Pseudo Obstruction
- Chronic Myelogenous Leukemia (CML) - Blast Phase
- CIC-rearranged Sarcoma
- Coffin-Lowry Syndrome
- Congenital Lymphedema
- Congenital Myotonic Dystrophy
- Congenital Zika Syndrome
- Cornelia de Lange Syndrome - Classic Form
- Corticobasal Degeneration
- Costello Syndrome (New)
- Creutzfeldt-Jakob Disease (CJD) – Adult
- Cri du Chat Syndrome
- Degos Disease - Systemic
- DeSanctis Cacchione Syndrome
- Desmoplastic Mesothelioma
- Desmoplastic Small Round Cell Tumors
- Dravet Syndrome
- Duchenne Muscular Dystrophy- Adult
- Early-Onset Alzheimer’s Disease
- Edwards Syndrome (Trisomy 18)
- Eisenmenger Syndrome
- Endometrial Stromal Sarcoma
- Endomyocardial Fibrosis
- Ependymoblastoma (Child Brain Cancer)
- Erdheim Chester Disease
- Esophageal Cancer
- Esthesioneuroblastoma
- Ewing Sarcoma
- Farber's Disease (FD) – Infantile
- Fatal Familial Insomnia
- Fibrodysplasia Ossificans Progressiva
- Fibrolamellar Cancer
- Follicular Dendritic Cell Sarcoma - metastatic or recurrent
- FOXG1 Syndrome
- Friedreich's Ataxia (FRDA)
- Frontotemporal Dementia (FTD), Pick's Disease -Type A – Adult
- Fryns Syndrome
- Fucosidosis - Type 1
- Fukuyama Congenital Muscular Dystrophy
- Fulminant Giant Cell Myocarditis
- Galactosialidosis - Early and Late Infantile Types
- Gallbladder Cancer
- Gaucher Disease (GD) - Type 2
- Gerstmann-Straussler-Scheinker Disease
- Giant Axonal Neuropathy
- Glioblastoma Multiforme (Brain Cancer)
- Glioma - Grade III and IV
- Glutaric Acidemia - Type II
- GM1 Gangliosidosis - Infantile and Juvenile Forms
- Harlequin Ichthyosis – Child (New)
- Head and Neck Cancers - with distant metastasis or inoperable or unresectable
- Heart Transplant Graft Failure
- Hematopoietic Stem Cell Transplantation (New)
- Hemophagocytic Lymphohistiocytosis (HLH) - Familial Type
- Hepatoblastoma
- Hepatocellular Carcinoma
- Hepatopulmonary Syndrome
- Hepatorenal Syndrome
- Histiocytic Malignancies (New)
- Histiocytosis Syndromes
- Hoyeraal-Hreidarsson Syndrome
- Hutchinson-Gilford Progeria Syndrome
- Hydranencephaly
- Hypocomplementemic Urticarial Vasculitis Syndrome
- Hypophosphatasia Perinatal (Lethal) and Infantile Onset Types
- Hypoplastic Left Heart Syndrome
- I Cell Disease
- Idiopathic Pulmonary Fibrosis
- Infantile Free Sialic Acid Storage Disease
- Infantile Neuroaxonal Dystrophy (INAD)
- Infantile Neuronal Ceroid Lipofuscinoses
- Inflammatory Breast Cancer (IBC)
- Intracranial Hemangiopericytoma
- Jervell and Lange-Nielsen Syndrome
- Joubert Syndrome
- Junctional Epidermolysis Bullosa - Lethal Type
- Juvenile Onset Huntington Disease
- Kidney Cancer - inoperable or unresectable
- Kleefstra Syndrome
- Krabbe Disease (KD) – Infantile
- Kufs Disease - Type A and B
- Large Intestine Cancer - with distant metastasis or inoperable, unresectable or recurrent
- Late Infantile Neuronal Ceroid Lipofuscinoses
- Leber Congenital Amaurosis
- Leigh’s Disease
- Leiomyosarcoma
- Leptomeningeal Carcinomatosis
- Lesch-Nyhan Syndrome (LNS)
- Lewy Body Dementia
- Liposarcoma - metastatic or recurrent
- Lissencephaly
- LMNA-related Congenital Muscular Dystrophy (New)
- Lowe Syndrome
- Lymphomatoid Granulomatosis - Grade III
- Malignant Brain Stem Gliomas – Childhood
- Malignant Ectomesenchymoma
- Malignant Gastrointestinal Stromal Tumor
- Malignant Germ Cell Tumor
- Malignant Multiple Sclerosis
- Malignant Renal Rhabdoid Tumor
- Mantle Cell Lymphoma (MCL)
- Maple Syrup Urine Disease
- Marshall-Smith Syndrome
- Mastocytosis - Type IV
- MECP2 Duplication Syndrome
- Medulloblastoma
- Megacystis Microcolon Intestinal Hypoperistalsis Syndrome
- Megalencephaly Capillary Malformation Syndrome
- Menkes Disease - Classic or Infantile Onset Form
- Merkel Cell Carcinoma - with metastases
- Merosin Deficient Congenital Muscular Dystrophy
- Metachromatic Leukodystrophy (MLD) - Late Infantile
- Metastatic Endometrial Adenocarcinoma
- Microvillus Inclusion Disease – Child
- Mitral Valve Atresia
- Mixed Dementias
- Mowat-Wilson Syndrome
- MPS I, formerly known as Hurler Syndrome
- MPS II, formerly known as Hunter Syndrome
- MPS III, formerly known as Sanfilippo Syndrome
- Mucosal Malignant Melanoma
- Multicentric Castleman Disease
- Multiple System Atrophy
- Myelodysplastic Syndrome with Excess Blasts
- Myoclonic Epilepsy with Ragged Red Fibers Syndrome
- Neonatal Adrenoleukodystrophy
- Neonatal Marfan Syndrome (New)
- Nephrogenic Systemic Fibrosis
- Neurodegeneration with Brain Iron Accumulation - Types 1 and 2
- NFU-1 Mitochondrial Disease
- Nicolaides-Baraister Syndrome
- Niemann-Pick Disease (NPD) - Type A
- Niemann-Pick Disease-Type C
- Nonketotic Hyperglycinemia
- Non-Small Cell Lung Cancer
- NUT Carcinoma
- Obliterative Bronchiolitis
- Ohtahara Syndrome
- Oligodendroglioma Brain Cancer- Grade III
- Ornithine Transcarbamylase (OTC) Deficiency
- Orthochromatic Leukodystrophy with Pigmented Glia
- Osteogenesis Imperfecta (OI) - Type II
- Osteosarcoma, formerly known as Bone Cancer - with distant metastases or inoperable or unresectable
- Ovarian Cancer – with distant metastases or inoperable or unresectable
- PACS1 Syndrome (New)
- Pallister-Killian Syndrome
- Pancreatic Cancer
- Paraneoplastic Cerebellar Degeneration
- Paraneoplastic Pemphigus
- Patau Syndrome (Trisomy 13)
- Pearson Syndrome
- Pelizaeus-Merzbacher Disease-Classic Form
- Pelizaeus-Merzbacher Disease-Connatal Form
- Pericardial Mesothelioma
- Peripheral Nerve Cancer - metastatic or recurrent
- Peritoneal Mesothelioma
- Peritoneal Mucinous Carcinomatosis
- Perry Syndrome
- Pfeiffer Syndrome - Types II and III
- Phelan-McDermid Syndrome
- Pineoblastoma - Childhood
- Pitt Hopkins Syndrome
- Plasmablastic Lymphoma (New)
- Pleural Mesothelioma
- Pompe Disease – Infantile
- Pontocerebellar Hypoplasia
- Posterior Cortical Atrophy
- Primary Central Nervous System Lymphoma
- Primary Effusion Lymphoma
- Primary Omental Cancer
- Primary Peritoneal Cancer
- Primary Progressive Aphasia
- Progressive Bulbar Palsy
- Progressive Muscular Atrophy (New)
- Progressive Multifocal Leukoencephalopathy
- Progressive Supranuclear Palsy
- Prostate Cancer - Hormone Refractory Disease – or with visceral metastases
- Pulmonary Atresia
- Pulmonary Amyloidosis – AL Type (New)
- Rasmussen Encephalitis (New)
- Refractory Hodgkin Lymphoma
- Renal Amyloidosis - AL Type
- Renal Medullary Carcinoma (New)
- Renpenning Syndrome
- Retinopathy of Prematurity - Stage V
- Rett (RTT) Syndrome
- Revesz Syndrome
- Rhabdomyosarcoma
- Rhizomelic Chondrodysplasia Punctata
- Richter Syndrome
- Roberts Syndrome
- Rubinstein-Taybi Syndrome
- Salivary Cancers
- Sandhoff Disease
- Sarcomatoid Carcinoma of the Lung - Stages II-IV
- Sarcomatoid Mesothelioma
- Schindler Disease - Type 1
- SCN8A Related Epilepsy with Encephalopathy
- Seckel Syndrome
- Secondary Adenocarcinoma of the Brain
- Severe Combined Immunodeficiency - Childhood
- Single Ventricle
- Sinonasal Cancer
- Sjogren-Larsson Syndrome
- Skin Malignant Melanoma with Metastases
- Small Cell Cancer - Large Intestine
- Small Cell Cancer - Prostate
- Small Cell Cancer - Thymus
- Small Cell Cancer of the Female Genital Tract
- Small Cell Lung Cancer
- Small Intestine Cancer - with distant metastases or inoperable, unresectable or recurrent
- Smith Lemli Opitz Syndrome
- Snijders Blok-Campeau Syndrome (New)
- Soft Tissue Sarcoma - with distant metastases or recurrent
- Spinal Muscular Atrophy (SMA) - Types 0 and 1
- Spinal Nerve Root Cancer-metastatic or recurrent
- Spinocerebellar Ataxia
- Stiff Person Syndrome
- Stomach Cancer - with distant metastases or inoperable, unresectable or recurrent
- Subacute Sclerosing Panencephalitis
- Superficial Siderosis of the Central Nervous System
- SYNGAP1-related NSID
- Tabes Dorsalis
- Tay Sachs Disease - Infantile Type
- Taybi-Linder Syndrome
- Tetrasomy 18p
- Thanatophoric Dysplasia - Type 1
- Thyroid Cancer
- Thymic Carcinoma (New)
- Transplant Coronary Artery Vasculopathy
- Tricuspid Atresia
- Trisomy 9
- Turnpenny-Fry Syndrome (New)
- Ullrich Congenital Muscular Dystrophy
- Ureter Cancer - with distant metastases or inoperable, unresectable or recurrent
- Usher Syndrome - Type I
- Ventricular Assist Device Recipient - Left, Right, or Biventricular
- Walker Warburg Syndrome
- WHO Grade III Meningiomas (New)
- Wolf-Hirschhorn Syndrome
- Wolman Disease
- X-Linked Lymphoproliferative Disease
- X-Linked Myotubular Myopathy
- Xeroderma Pigmentosum
- Zellweger Syndrome
- Zhu-Tokita-Takenouchi-Kim Syndrome (New)
You can find detailed information for your compassionate allowance condtion on the SSA.gov page for compassionate allowances:
This information is sourced from: Social Security Administration. (n.d.). Compassionate Allowances Conditions. https://www.ssa.gov/compassionateallowances/conditions.htm. Retrieved January 26, 2025, updated September 2, 2025.
See SSA Press Release of August 11, 2025: https://www.ssa.gov/news/en/press/releases/2025-08-11.html for the 13 new Compassionate Allowances (included on this page).